Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | DHODH | Q02127 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6771481 | 0.88 | OPRM1 (0.43) | OPRM1ALDH1A1DHODHSMN1; SMN2NR3C1 | |
| SCHEMBL6767785 | 0.88 | L3MBTL1 (0.39) | OPRM1L3MBTL1ALDH1A1LMNADHODH | |
| SCHEMBL6167296 | 0.87 | HIF1A (0.47) | OPRM1ALDH1A1LMNADHODHSMN1; SMN2 | |
| SCHEMBL6771511 | 0.86 | L3MBTL1 (0.49) | OPRM1L3MBTL1ALDH1A1LMNAPKM | |
| SCHEMBL6769850 | 0.85 | OPRM1 (0.38) | OPRM1L3MBTL1ALDH1A1LMNADHODH | |
| SCHEMBL7490727 | 0.84 | L3MBTL1 (0.36) | OPRM1L3MBTL1ALDH1A1LMNADHODH | |
| SCHEMBL6769465 | 0.82 | ALDH1A1 (0.36) | OPRM1L3MBTL1ALDH1A1LMNADHODH | |
| SCHEMBL6769819 | 0.82 | OPRM1 (0.43) | OPRM1L3MBTL1ALDH1A1LMNADHODH | |
| SCHEMBL6771990 | 0.79 | OPRM1 (0.54) | OPRM1ALDH1A1LMNAPKMSMN1; SMN2 | |
| SCHEMBL6770505 | 0.79 | OPRM1 (0.46) | OPRM1L3MBTL1DHODHSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |