Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6777339 | 0.89 | CASP1 (0.39) | OPRM1MGLLSRCDHODHMAPT | |
| SCHEMBL6770575 | 0.88 | GPBAR1 (0.39) | OPRM1MGLLSRCDHODHMAPT | |
| SCHEMBL6769819 | 0.87 | OPRM1 (0.43) | OPRM1SRCDHODHMAPTSMN1; SMN2 | |
| SCHEMBL6766674 | 0.87 | RIPK2 (0.46) | MGLLSRCDHODHMAPTRAB9A | |
| SCHEMBL6772551 | 0.86 | DHODH (0.37) | MGLLSRCDHODHMAPTRAB9A | |
| SCHEMBL6167296 | 0.86 | HIF1A (0.47) | OPRM1DHODHMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL6766574 | 0.85 | ALDH1A1 (0.39) | MGLLDHODHMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL6772063 | 0.85 | OPRM1 (0.48) | OPRM1MGLLSRCMAPTRAB9A | |
| SCHEMBL6770636 | 0.81 | RIPK2 (0.35) | MGLLSRCDHODHMAPTRAB9A | |
| SCHEMBL6770476 | 0.79 | OPRM1 (0.45) | OPRM1MGLLDHODHMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |