Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | BRS3 | P32247 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6165012 | 0.94 | ALOX5 (0.42) | ALOX5MAPTMAPK1SMN1; SMN2SETD7 | |
| SCHEMBL6163170 | 0.87 | SMN1; SMN2 (0.52) | ALOX5MAPTMAPK1SMN1; SMN2MRGPRX4 | |
| SCHEMBL6162975 | 0.85 | MAPK14 (0.44) | ALOX5MAPTMAPK1SMN1; SMN2BRS3 | |
| SCHEMBL6166441 | 0.85 | MMP2 (0.42) | ALOX5MAPTMAPK1PTGESTLR8 | |
| SCHEMBL6163317 | 0.82 | MAPT (0.56) | ALOX5MAPTMAPK1SMN1; SMN2PTGES | |
| SCHEMBL6163789 | 0.81 | ALOX5 (0.38) | ALOX5MAPTMAPK1SMN1; SMN2BRS3 | |
| SCHEMBL6162430 | 0.81 | SMN1; SMN2 (0.60) | ALOX5MAPTMAPK1SMN1; SMN2PTGES | |
| SCHEMBL6166329 | 0.80 | ALOX5 (0.35) | ALOX5MAPTMAPK1SETD7POLB | |
| SCHEMBL6162773 | 0.79 | MAPT (0.48) | ALOX5MAPTMAPK1SMN1; SMN2SETD7 | |
| SCHEMBL6165221 | 0.79 | MAPT (0.48) | ALOX5MAPTMAPK1SMN1; SMN2MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254136-A4 | FACTOR Xa INHIBITORS WITH ARYL-AMIDINES AND DERIVATIVES, AND PRODRUGS THEREOF | LG CHEM INVESTMENT LTD (KR) | 2005-06-01 | — | — | EP | disclosed |
| EP-1254136-A1 | FACTOR Xa INHIBITORS WITH ARYL-AMIDINES AND DERIVATIVES, AND PRODRUGS THEREOF | LG Chem Investment, Ltd. (KR) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001055146-A1 | FACTOR Xa INHIBITORS WITH ARYL-AMIDINES AND DERIVATIVES, AND PRODRUGS THEREOF | LG CHEM INVESTMENT LTD. (KR) | 2001-08-02 | — | — | WO | disclosed |