SCHEMBL6166441

SCHEMBL6166441

CCOC(=O)c1c(-c2ccc(-c3cccnc3)cc2)c[nH]c1Cc1cccc(C#N)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 1/20 0.42
MMP13 P45452 1/20 0.42
MMP14 P50281 1/20 0.42
NEK1 Q96PY6 1/20 0.42
ALOX5 P09917 2/20 0.42
ITK Q08881 1/20 0.39
CYP11B2 P19099 2/20 0.38
CYP19A1 P11511 1/20 0.38
CYP11B1 P15538 1/20 0.38
BTK Q06187 2/20 0.38
CACNA1C Q13936 1/20 0.38
TLR8 Q9NR97 1/20 0.38
TLR7 Q9NYK1 1/20 0.38
HRH3 Q9Y5N1 1/20 0.38
PAX8 Q06710 1/20 0.38
PDK1 Q15118 1/20 0.38
MAPT P10636 1/20 0.38
MAPK1 P28482 1/20 0.38
STK10 O94804 2/20 0.37
SLK Q9H2G2 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6165012 0.86 ALOX5 (0.42) ALOX5TLR8TLR7MAPTMAPK1
SCHEMBL6165006 0.85 ALOX5 (0.43) ALOX5TLR8TLR7MAPTMAPK1
SCHEMBL6162975 0.84 MAPK14 (0.44) ALOX5BTKTLR8TLR7MAPT
Trifluoroacetic Acid SCHEMBL6164576 0.79 F10 (0.46) MMP2MMP13MMP14ALOX5
SCHEMBL6163317 0.78 MAPT (0.56) ALOX5HRH3MAPTMAPK1PTGES
SCHEMBL6163789 0.78 ALOX5 (0.38) ALOX5TLR8TLR7MAPTMAPK1
SCHEMBL6166329 0.77 ALOX5 (0.35) MMP13ALOX5BTKTLR8TLR7
SCHEMBL6166443 0.77 ELANE (0.44) MMP2MMP13MMP14ITKCYP11B2
SCHEMBL6162430 0.76 SMN1; SMN2 (0.60) ALOX5MAPTMAPK1PTGES
SCHEMBL6161520 0.75 SMN1; SMN2 (0.53) ALOX5MAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1254136-A4 FACTOR Xa INHIBITORS WITH ARYL-AMIDINES AND DERIVATIVES, AND PRODRUGS THEREOF LG CHEM INVESTMENT LTD (KR) 2005-06-01 EP disclosed
EP-1254136-A1 FACTOR Xa INHIBITORS WITH ARYL-AMIDINES AND DERIVATIVES, AND PRODRUGS THEREOF LG Chem Investment, Ltd. (KR) 2002-11-06 EP disclosed
WO-2001055146-A1 FACTOR Xa INHIBITORS WITH ARYL-AMIDINES AND DERIVATIVES, AND PRODRUGS THEREOF LG CHEM INVESTMENT LTD. (KR) 2001-08-02 WO disclosed