Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.32 |
| ▸ | KDM4A | O75164 | 1/20 | 0.32 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28988373 | 1.00 | LMNA (0.50) | LMNAKDM4CKDM4APHF8KDM2A | |
| SCHEMBL28491812 | 0.97 | LMNA (0.53) | LMNABLM | |
| SCHEMBL3626089 | 0.90 | — | — | |
| SCHEMBL11723029 | 0.83 | LMNA (0.67) | LMNAKDM4CKDM4APHF8KDM2A | |
| SCHEMBL21925059 | 0.83 | LMNA (0.67) | LMNAKDM4CKDM4APHF8KDM2A | |
| SCHEMBL2568120 | 0.83 | — | — | |
| SCHEMBL20530387 | 0.83 | LMNA (0.67) | LMNAKDM4CKDM4APHF8KDM2A | |
| SCHEMBL7580335 | 0.83 | LMNA (0.67) | LMNAKDM4CKDM4APHF8KDM2A | |
| SCHEMBL20494560 | 0.83 | — | — | |
| SCHEMBL11207754 | 0.83 | LMNA (0.67) | LMNAKDM4CKDM4APHF8KDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878726-B2 | Pyrazole ether derivatives as anti-inflammatory/analgesic agents | PFIZER INC. (US) | 2005-04-12 | — | — | US | disclosed |
| EP-1233959-B1 | HETEROCYCLO-ALKYLSULFONYL PYRAZOLE DERIVATIVES AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER PROD INC (US) | 2005-03-16 | — | — | EP | disclosed |
| US-20050004135-A1 | Pyrazole ether derivatives as anti-inflammatory/analgesic agents | CHENG HENGMAIO (US) | 2005-01-06 | — | — | US | disclosed |
| US-20040259879-A1 | Pyrazole ether derivatives as anti-inflammatory/analgesic agents | CHENG HENGMAIO (US) | 2004-12-23 | — | — | US | disclosed |
| US-20030236258-A1 | Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents | PFIZER INC. | 2003-12-25 | — | — | US | disclosed |
| US-6531492-B1 | Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents | PFIZER INC. | 2003-03-11 | — | — | US | disclosed |
| EP-1259504-A1 | PYRAZOLE ETHER DERIVATIVES AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | Pfizer Products Inc. (US) | 2002-11-27 | — | — | EP | disclosed |
| EP-1233959-A1 | HETEROCYCLO-ALKYLSULFONYL PYRAZOLE DERIVATIVES AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | Pfizer Products Inc. (US) | 2002-08-28 | — | — | EP | disclosed |
| US-20020058681-A1 | Pyrazole ether derivatives as anti-inflammatory/analgesic agents | PFIZER INC. | 2002-05-16 | — | — | US | disclosed |
| WO-2001064669-A1 | PYRAZOLE ETHER DERIVATIVES AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER PRODUCTS INC. (US) | 2001-09-07 | — | — | WO | disclosed |
| WO-2001040216-A1 | HETEROCYCLO-ALKYLSULFONYL PYRAZOLE DERIVATIVES AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER PRODUCTS INC. (US) | 2001-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020058681-A1 | Pyrazole ether derivatives as anti-inflammatory/analgesic agents | PTGER3, PTGER1, P2RX3 | LMNA 4357/4885KDM4C 1974/4885KDM4A 1605/4885 |
| US-20030236258-A1 | Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents | PTGS1, SULT2A1, PTGES3 | LMNA 4448/4885KDM4C 2489/4885KDM4A 2507/4885 |
| US-20050004135-A1 | Pyrazole ether derivatives as anti-inflammatory/analgesic agents | P2RX3, P2RX7, PTGER3 | LMNA 4436/4885KDM4C 1235/4885KDM4A 1049/4885 |
| US-20040259879-A1 | Pyrazole ether derivatives as anti-inflammatory/analgesic agents | PTGER3, PTGER1, P2RX3 | LMNA 4357/4885KDM4C 1974/4885KDM4A 1605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.