Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14355821 | 0.85 | MEN1 (0.49) | MEN1KMT2AATMLMNAALDH1A1 | |
| SCHEMBL14356017 | 0.82 | HTR1A (0.48) | LMNACXCR4 | |
| SCHEMBL20884934 | 0.77 | LMNA (0.56) | MEN1KMT2AATMLMNAALDH1A1 | |
| SCHEMBL7923468 | 0.77 | LMNA (0.57) | MEN1KMT2ALMNAALDH1A1TSHR | |
| SCHEMBL12075014 | 0.76 | LMNA (0.42) | MEN1KMT2AATMLMNAALDH1A1 | |
| SCHEMBL20884932 | 0.76 | HTR6 (0.44) | LMNAALDH1A1TSHRCYP1A2CHRM2 | |
| SCHEMBL16744506 | 0.76 | CXCR4 (0.48) | LMNACYP1A2CHRM2SLC6A4OPRD1 | |
| SCHEMBL14387748 | 0.76 | MGLL (0.55) | ALDH1A1HTR1DCYP2D6SIGMAR1 | |
| SCHEMBL5340446 | 0.75 | MGLL (0.49) | MEN1KMT2AATMLMNAALDH1A1 | |
| SCHEMBL22422339 | 0.75 | ADRB1 (0.54) | LMNACYP1A2HTR6DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7291619-B2 | Melanocortin receptor agonists | ELI LILLY AND COMPANY (US) | 2007-11-06 | — | — | US | disclosed |
| US-7291619-B2 | Melanocortin receptor agonists | ELI LILLY AND COMPANY (US) | 2007-11-06 | — | — | US | disclosed |
| EP-1368340-B1 | PIPERAZINE DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS | LILLY CO ELI (US) | 2005-08-10 | — | — | EP | disclosed |