Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | HTR2C | P28335 | 7/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | HTR1F | P30939 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 6/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6335588 | 0.94 | HTR6 (0.60) | HTR6HDAC1HDAC2HDAC6HTR2C | |
| SCHEMBL6330560 | 0.82 | HTR6 (0.58) | HTR6HDAC1HDAC2HDAC6HTR1A | |
| SCHEMBL6336170 | 0.78 | PNMT (0.50) | HTR6HTR2CHTR2BCYP3A4HTR2A | |
| SCHEMBL1171841 | 0.78 | HTR6 (1.00) | HTR6HDAC1HDAC2HDAC6HTR1A | |
| SCHEMBL3248158 | 0.76 | HTR6 (1.00) | HTR6HDAC1HDAC2HDAC6HTR1A | |
| SCHEMBL6330390 | 0.76 | HTR6 (0.65) | HTR6HTR2CHTR2BCYP3A4HTR2A | |
| SCHEMBL6166337 | 0.76 | HTR2C (0.59) | HTR6HTR2CHTR2B | |
| SCHEMBL6332174 | 0.73 | HTR6 (0.41) | HTR6HTR2CDRD2DRD3HTR2A | |
| SCHEMBL6330346 | 0.72 | HTR6 (0.58) | HTR6HTR1ADRD2HTR7HTR2A | |
| SCHEMBL6167732 | 0.72 | HTR6 (0.65) | HTR6HTR2CHTR2BCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392316-B1 | BENZO[D]AZEPINE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS. | SMITHKLINE BEECHAM PLC (GB) | 2005-04-20 | — | — | EP | claimed |
| US-20040192671-A1 | Benzo[d]azepine derivatives as 5-ht6 receptor anatagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-09-30 | — | — | US | claimed |
| EP-1392316-A1 | BENZO[D]AZEPINE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS. | SMITHKLINE BEECHAM PLC (GB) | 2004-03-03 | — | — | EP | claimed |
| WO-2002089811-A1 | BENZO[D]AZEPINE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS. | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-11-14 | — | — | WO | claimed |
| EP-1392316-B1 | BENZO[D]AZEPINE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS. | SMITHKLINE BEECHAM PLC (GB) | 2005-04-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192671-A1 | Benzo[d]azepine derivatives as 5-ht6 receptor anatagonists | HTR6, HTR5A, HTR1A | HTR6 1/4885HDAC1 3577/4885HDAC2 4000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.