Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.36 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.36 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164331 | 0.84 | DHODH (0.34) | — | |
| SCHEMBL6168175 | 0.84 | CSNK2A2 (0.33) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6167888 | 0.82 | HTT (0.39) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6166641 | 0.81 | ALPL (0.40) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6167029 | 0.77 | CSNK2A2 (0.39) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6770545 | 0.76 | ABCG2 (0.38) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6167293 | 0.76 | HTT (0.42) | ABCG2CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL6166292 | 0.74 | HTT (0.36) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6165077 | 0.74 | CCNA2 (0.45) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6163402 | 0.73 | ALPL (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |