Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 3/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.45 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.45 |
| ▸ | PDE2A | O00408 | 3/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168238 | 0.78 | NPC1 (0.51) | ALDH1A1GAAMMP2MMP13SIRT2 | |
| SCHEMBL6168135 | 0.77 | LMNA (0.49) | ALDH1A1GAAMMP2MMP13SIRT2 | |
| SCHEMBL6167465 | 0.76 | L3MBTL1 (0.47) | ALDH1A1GAACNR1MMP2MMP13 | |
| SCHEMBL6168721 | 0.75 | CNR1 (0.54) | ALDH1A1GAACNR1MMP2MMP13 | |
| SCHEMBL7486579 | 0.72 | CNR1 (0.59) | FAAHALDH1A1GAACNR1LMNA | |
| SCHEMBL9233657 | 0.70 | MMP13 (0.71) | ALDH1A1MMP2MMP13LMNA | |
| SCHEMBL542696 | 0.70 | MMP13 (0.71) | ALDH1A1MMP2MMP13LMNA | |
| SCHEMBL6169138 | 0.69 | CNR1 (0.49) | ALDH1A1GAACNR1MMP2MMP13 | |
| SCHEMBL5954451 | 0.69 | MEN1 (0.44) | ALDH1A1SIRT2SIRT1SIRT5PDE2A | |
| SCHEMBL9893251 | 0.69 | KCNA5 (0.51) | AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546111-A2 | 2-THIOHYDANTOINE DERIVATIVE COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF DIABETES | LABORATOIRES FOURNIER S.A. (FR) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004031160-A2 | 2-THIOHYDANTOINE DERIVATIVE COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF DIABETES | LABORATOIRES FOURNIER S.A. (FR) | 2004-04-15 | — | — | WO | disclosed |