Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | PTGES | O14684 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168238 | 0.92 | NPC1 (0.51) | L3MBTL1NPC1RAB9AMMP2MMP13 | |
| SCHEMBL6168135 | 0.91 | LMNA (0.49) | L3MBTL1NPC1RAB9AMMP2MMP13 | |
| SCHEMBL6167053 | 0.86 | CNR1 (0.49) | L3MBTL1CNR1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL6167711 | 0.77 | CNR1 (0.50) | MMP2MMP13CNR1ALDH1A1TSHR | |
| SCHEMBL6169738 | 0.77 | CNR1 (0.43) | MMP2MMP13CNR1ALDH1A1KDM4E | |
| SCHEMBL6169070 | 0.76 | FAAH (0.50) | MMP2MMP13CNR1SIRT2SIRT1 | |
| SCHEMBL6168870 | 0.76 | GAA (0.46) | RAB9AMMP2MMP13CNR1SMN1; SMN2 | |
| SCHEMBL7481341 | 0.75 | CNR1 (0.55) | CNR1ALDH1A1MAPTKDM4ETSHR | |
| SCHEMBL6168712 | 0.73 | CNR1 (0.46) | MMP2MMP13CNR1ALDH1A1MAPT | |
| SCHEMBL6628115 | 0.73 | CNR1 (0.49) | L3MBTL1NPC1RAB9ACNR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546111-A2 | 2-THIOHYDANTOINE DERIVATIVE COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF DIABETES | LABORATOIRES FOURNIER S.A. (FR) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004031160-A2 | 2-THIOHYDANTOINE DERIVATIVE COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF DIABETES | LABORATOIRES FOURNIER S.A. (FR) | 2004-04-15 | — | — | WO | disclosed |