Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 2/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169940 | 0.82 | TDP1 (0.50) | GAATSHRALDH1A1POLBHSD17B10 | |
| SCHEMBL4738735 | 0.74 | AGER (0.49) | AGERMTNR1AGAATSHRALDH1A1 | |
| SCHEMBL4737580 | 0.74 | AGER (0.51) | AGERMTNR1AGAATSHRALDH1A1 | |
| SCHEMBL25911207 | 0.73 | OPRM1 (0.47) | AGERMTNR1AOPRM1TSHRALDH1A1 | |
| SCHEMBL4738946 | 0.72 | ALDH1A1 (0.43) | AGERGAATSHRALDH1A1LMNA | |
| SCHEMBL27978853 | 0.72 | L3MBTL1 (0.59) | GAATSHRALDH1A1HSD17B10 | |
| SCHEMBL8178807 | 0.70 | TAAR1 (0.42) | DPP4DPP9DPP7GAATSHR | |
| SCHEMBL10487075 | 0.68 | ALDH1A1 (0.53) | GAAALDH1A1HDAC6 | |
| SCHEMBL25668709 | 0.67 | DPP4 (0.46) | DPP4DPP9DPP7TSHRALDH1A1 | |
| SCHEMBL25668895 | 0.67 | DPP4 (0.43) | DPP4DPP9DPP7GAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519920-A1 | NOVEL TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2005-04-06 | — | — | EP | disclosed |
| WO-2004002957-A1 | NOVEL TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2004-01-08 | — | — | WO | disclosed |