Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169489 | 0.82 | AGER (0.47) | HSD17B10POLBALDH1A1GAATSHR | |
| SCHEMBL4738735 | 0.72 | AGER (0.49) | TP53L3MBTL1KMT2AHSD17B10ALDH1A1 | |
| SCHEMBL27978853 | 0.72 | L3MBTL1 (0.59) | TP53L3MBTL1HSD17B10ALDH1A1GAA | |
| SCHEMBL4738946 | 0.72 | ALDH1A1 (0.43) | TP53L3MBTL1KMT2AHSD17B10ALDH1A1 | |
| SCHEMBL4737580 | 0.71 | AGER (0.51) | L3MBTL1KMT2AALDH1A1GAATSHR | |
| SCHEMBL15379656 | 0.70 | TDP1 (0.66) | TDP1KMT2APOLBALDH1A1GAA | |
| SCHEMBL2674850 | 0.69 | TSHR (0.47) | L3MBTL1KMT2AHSD17B10ALDH1A1GAA | |
| SCHEMBL6170665 | 0.68 | ROCK2 (0.55) | TP53L3MBTL1ROCK2ROCK1KMT2A | |
| SCHEMBL1515837 | 0.67 | SMN1; SMN2 (0.57) | TDP1KMT2AALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL17005404 | 0.67 | REN (0.50) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519920-A1 | NOVEL TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2005-04-06 | — | — | EP | disclosed |
| WO-2004002957-A1 | NOVEL TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2004-01-08 | — | — | WO | disclosed |