Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 7/20 | 0.69 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | GRK5 | P34947 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167711 | 0.83 | CNR1 (0.50) | CNR1MGLLGRK5TYRO3DYRK1B | |
| SCHEMBL6169639 | 0.80 | CNR1 (0.47) | CNR1MGLLGRK5TYRO3DYRK1B | |
| SCHEMBL6168712 | 0.76 | CNR1 (0.46) | CNR1MGLLGRK5TYRO3DYRK1B | |
| SCHEMBL6168870 | 0.76 | GAA (0.46) | CNR1MGLLMMP2MMP3MMP9 | |
| SCHEMBL6169738 | 0.75 | CNR1 (0.43) | CNR1MGLLMMP2MMP3MMP9 | |
| SCHEMBL4519510 | 0.73 | BACE1 (0.44) | FAAHNTRK1IGF1RFGFR1NTRK2 | |
| SCHEMBL6167462 | 0.73 | CNR1 (0.41) | CNR1MGLLMMP2MMP3MMP9 | |
| SCHEMBL6168079 | 0.73 | LMNA (0.47) | CNR1MGLLMMP2MMP3MMP9 | |
| SCHEMBL6168455 | 0.73 | PGR (0.41) | CNR1MGLLFAAHMMP2MMP3 | |
| SCHEMBL6167893 | 0.72 | ELANE (0.45) | CNR1MGLLMMP2MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546111-A2 | 2-THIOHYDANTOINE DERIVATIVE COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF DIABETES | LABORATOIRES FOURNIER S.A. (FR) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004031160-A2 | 2-THIOHYDANTOINE DERIVATIVE COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF DIABETES | LABORATOIRES FOURNIER S.A. (FR) | 2004-04-15 | — | — | WO | disclosed |