Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | HTR7 | P34969 | 5/20 | 0.41 |
| ▸ | HTR1A | P08908 | 4/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | GRK5 | P34947 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167711 | 0.93 | CNR1 (0.50) | CNR1MMP2MMP3MMP9MMP8 | |
| SCHEMBL6170930 | 0.89 | HSD11B1 (0.44) | DRD2HTR7HTR1AALDH1A1MEN1 | |
| SCHEMBL6168455 | 0.89 | PGR (0.41) | CNR1DRD2HTR7HTR1AMMP2 | |
| SCHEMBL6168870 | 0.86 | GAA (0.46) | CNR1MMP2MMP3MMP9MMP8 | |
| SCHEMBL6169738 | 0.85 | CNR1 (0.43) | CNR1MMP2MMP3MMP9MMP8 | |
| SCHEMBL7481341 | 0.83 | CNR1 (0.55) | CNR1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL6168079 | 0.82 | LMNA (0.47) | CNR1MMP2MMP3MMP9MMP8 | |
| SCHEMBL6167462 | 0.82 | CNR1 (0.41) | CNR1MMP2MMP3MMP9MMP8 | |
| SCHEMBL6169535 | 0.78 | HSD17B3 (0.45) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL6170632 | 0.76 | ALDH1A1 (0.46) | MMP13ALDH1A1MAPTGAADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546111-A2 | 2-THIOHYDANTOINE DERIVATIVE COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF DIABETES | LABORATOIRES FOURNIER S.A. (FR) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004031160-A2 | 2-THIOHYDANTOINE DERIVATIVE COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF DIABETES | LABORATOIRES FOURNIER S.A. (FR) | 2004-04-15 | — | — | WO | disclosed |