Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.55 |
| ▸ | SIRT5 | Q9NXA8 | 4/20 | 0.55 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169513 | 0.85 | L3MBTL1 (0.48) | SIRT1SIRT5MAPTL3MBTL1MEN1 | |
| SCHEMBL5955353 | 0.73 | SIRT1 (0.52) | SIRT1SIRT5SIRT2SIRT3MAPT | |
| SCHEMBL5954486 | 0.72 | SIRT1 (0.49) | SIRT1SIRT5SIRT2SIRT3MAPT | |
| SCHEMBL1597896 | 0.72 | GAA (0.70) | MAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL6167361 | 0.70 | GAA (0.58) | MAPTMEN1KMT2A | |
| SCHEMBL2293159 | 0.68 | GRM2 (0.43) | SIRT1SIRT5TP53MAOBMEN1 | |
| SCHEMBL6168233 | 0.68 | NPC1 (0.48) | SIRT1SIRT5SIRT2MAPTL3MBTL1 | |
| SCHEMBL2293787 | 0.68 | GRM2 (0.43) | SIRT1SIRT5TP53MAOBMEN1 | |
| SCHEMBL8769357 | 0.68 | ALDH1A1 (0.63) | TNKS2MAPTTP53MAOBMMP13 | |
| SCHEMBL19420143 | 0.68 | GAA (0.62) | SIRT1SIRT5MAPTL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546111-A2 | 2-THIOHYDANTOINE DERIVATIVE COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF DIABETES | LABORATOIRES FOURNIER S.A. (FR) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004031160-A2 | 2-THIOHYDANTOINE DERIVATIVE COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF DIABETES | LABORATOIRES FOURNIER S.A. (FR) | 2004-04-15 | — | — | WO | disclosed |