Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.41 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GPX4 | P36969 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170768 | 0.93 | TP53 (0.54) | MAPTTP53ALDH1A1HPGDTSHR | |
| SCHEMBL6170577 | 0.92 | TP53 (0.45) | MAPTTP53ALDH1A1HPGDTSHR | |
| SCHEMBL6171990 | 0.82 | ALDH1A1 (0.40) | MAPTTP53ALDH1A1HPGDTSHR | |
| SCHEMBL6612626 | 0.75 | ADORA2A (0.38) | TP53ALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL7470525 | 0.73 | ADORA2A (0.39) | MAPTTP53ALOX15HSD17B10LMNA | |
| SCHEMBL6171107 | 0.71 | ALDH1A1 (0.41) | MAPTTP53ALDH1A1HPGDTSHR | |
| SCHEMBL6172259 | 0.70 | TP53 (0.60) | MAPTTP53ALDH1A1HPGDTSHR | |
| SCHEMBL6170859 | 0.70 | ALDH1A1 (0.41) | MAPTTP53ALDH1A1HPGDTSHR | |
| SCHEMBL6613258 | 0.68 | LMNA (0.36) | TP53ALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL6611296 | 0.67 | LMNA (0.35) | MAPTTP53ALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263757-B1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2005-07-27 | — | — | EP | claimed |