Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 12/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 10/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170577 | 0.81 | TP53 (0.45) | ADORA2ALMNAPOLBTP53MAPT | |
| SCHEMBL6171650 | 0.77 | ALOX15 (0.58) | ADORA2ALMNATP53MAPTADORA1 | |
| SCHEMBL6171990 | 0.76 | ALDH1A1 (0.40) | ADORA2ALMNAPOLBTP53MAPT | |
| SCHEMBL6171107 | 0.74 | ALDH1A1 (0.41) | ADORA2ALMNATP53MAPTHSD17B10 | |
| SCHEMBL6170859 | 0.73 | ALDH1A1 (0.41) | ADORA2ATP53MAPTADORA1HSD17B10 | |
| SCHEMBL6170768 | 0.73 | TP53 (0.54) | ADORA2ALMNATP53MAPTADORA1 | |
| SCHEMBL6173367 | 0.73 | MAPT (0.48) | LMNATP53MAPTALOX15HSD17B10 | |
| SCHEMBL6173452 | 0.70 | ALDH1A1 (0.47) | ADORA2ALMNAPOLBTP53MAPT | |
| SCHEMBL6172259 | 0.69 | TP53 (0.60) | LMNATP53MAPTALOX15HSD17B10 | |
| SCHEMBL6612626 | 0.69 | ADORA2A (0.38) | ADORA2ALMNATP53ADORA1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263757-A1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | Darwin Discovery Limited (GB) | 2002-12-11 | — | — | EP | claimed |
| WO-2001058897-A1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-08-16 | — | — | WO | claimed |