SCHEMBL617207

SCHEMBL617207

Oc1ccc(F)cc1-c1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 2/20 0.62
ALDH1A1 P00352 2/20 0.54
HPGD P15428 2/20 0.54
HSD17B10 Q99714 2/20 0.54
BCL2L1 Q07817 1/20 0.54
PELI1 Q96FA3 1/20 0.49
ALOX5 P09917 2/20 0.48
HSD17B1 P14061 1/20 0.47
HSD17B2 P37059 1/20 0.47
IDO1 P14902 2/20 0.47
NPC1 O15118 1/20 0.47
KDM1A O60341 1/20 0.46
HDAC1 Q13547 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
PFKFB3 Q16875 1/20 0.44
MAOA P21397 1/20 0.44
MAOB P27338 1/20 0.44
CA3 P07451 1/20 0.43
CA6 P23280 1/20 0.43
CA5A P35218 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30146622 1.00 BACE1 (0.62) BACE1ALDH1A1HPGDHSD17B10BCL2L1
SCHEMBL27790650 0.94 BACE1 (0.56) BACE1ALDH1A1HPGDHSD17B10BCL2L1
SCHEMBL4621728 0.90 ALDH1A1 (0.54) BACE1ALDH1A1HPGDHSD17B10BCL2L1
SCHEMBL9743853 0.86 IDO1 (0.55) BACE1ALDH1A1HPGDHSD17B10IDO1
SCHEMBL16428977 0.85 ESR2 (0.53) BACE1HPGDHSD17B1HSD17B2IDO1
SCHEMBL14832985 0.84 ALOX5 (0.61) BACE1ALDH1A1HPGDHSD17B10BCL2L1
SCHEMBL17917596 0.81 NPC1 (0.60) IDO1NPC1LMNAMEN1KMT2A
SCHEMBL8059885 0.81 IDO1 (0.57) ALDH1A1HPGDHSD17B10IDO1NPC1
SCHEMBL31549500 0.80 NPC1 (0.48) ALDH1A1HPGDHSD17B10BCL2L1IDO1
SCHEMBL31349669 0.80 NPC1 (0.48) ALDH1A1HPGDHSD17B10BCL2L1IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-59170043-A None JP disclosed
US-10799510-B2 Derivatives of 6-substituted triazolopyridazines as Rev-Erb agonists GENFIT (FR) 2020-10-13 US disclosed
EP-2324067-B1 ETHYLENE COPOLYMER AND A METHOD OF PREPARING THE SAME SABIC SK NEXLENE COMPANY PTE LTD (SG) 2018-04-25 EP disclosed
US-20170296548-A1 DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS GENFIT (FR) 2017-10-19 US disclosed
US-9586963-B2 Derivatives of 6-substituted triazolopyridazines as Rev-Erb agonists GENFIT (FR) 2017-03-07 US disclosed
US-20150038503-A1 DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS GENFIT (FR) 2015-02-05 US disclosed
EP-2076551-B1 ARYLPHENOXY CATALYST SYSTEM FOR PRODUCING ETHYLENE HOMOPOLYMER OR COPOLYMERS OF ETHYLENE AND ALPHA-OLEFINS SK INNOVATION CO LTD (KR) 2014-08-06 EP disclosed
EP-2760866-A1 DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS Genfit (FR) 2014-08-06 EP disclosed
US-8674026-B2 Ethylene copolymer having multiple pitch in molecular weight distribution and the method of preparing the same SK INNOVATION CO., LTD. (KR) 2014-03-18 US disclosed
EP-2010576-B1 BIS-ARYLARYLOXY CATALYTIC SYSTEM FOR PRODUCING ETHYLENE HOMOPOLYMERS OR ETHYLENE COPOLYMERS WITH ALPHA-OLEFINS SK INNOVATION CO LTD (KR) 2013-07-24 EP disclosed
CN-101522727-A Arylphenoxy catalyst system for producing ethylene homopolymer or copolymers of ethylene and a-olefins SK ENERGY CO LTD 2009-09-02 CN disclosed
EP-2076551-A1 ARYLPHENOXY CATALYST SYSTEM FOR PRODUCING ETHYLENE HOMOPOLYMER OR COPOLYMERS OF ETHYLENE AND -OLEFINS SK Energy Co., Ltd. (KR) 2009-07-08 EP disclosed
WO-2009031798-A2 ETHYLENE COPOLYMER HAVING MULTIPLE PITCH IN MOLECULAR WEIGHT DISTRIBUTION AND THE METHOD OF PREPARING THE SAME SK ENERGY CO., LTD. (KR) 2009-03-12 WO disclosed
EP-2010576-A1 BIS-ARYLARYLOXY CATALYTIC SYSTEM FOR PRODUCING ETHYLENE HOMOPOLYMERS OR ETHYLENE COPOLYMERS WITH ALPHA-OLEFINS SK Energy Co., Ltd. (KR) 2009-01-07 EP disclosed
WO-2008047957-A1 ARYLPHENOXY CATALYST SYSTEM FOR PRODUCING ETHYLENE HOMOPOLYMER OR COPOLYMERS OF ETHYLENE AND α-OLEFINS SK ENERGY CO., LTD. (KR) 2008-04-24 WO disclosed
WO-2007123362-A1 BIS-ARYLARYLOXY CATALYTIC SYSTEM FOR PRODUCING ETHYLENE HOMOPOLYMERS OR ETHYLENE COPOLYMERS WITH ALPHA-OLEFINS SK ENERGY CO., LTD. (KR) 2007-11-01 WO disclosed
US-20070249490-A1 BIS-ARYLARYLOXY CATALYTIC SYSTEM FOR PRODUCING ETHYLENE HOMOPOLYMERS OR ETHYLENE COPOLYMERS WITH ALPHA-OLEFINS SK CORPORATION (KR) 2007-10-25 US disclosed
US-20070135297-A1 ARYLPHENOXY CATALYST SYSTEM FOR PRODUCING ETHYLENE HOMOPOLYMER OR COPOLYMERS OF ETHYLENE AND a-OLEFINS SK CORPORATION (KR) 2007-06-14 US disclosed
US-4558151-A FOR ELECTROOPTICAL DISPLAY DEVICES DAINIPPON INK AND CHEMICALS, INC. (JP) 1985-12-10 US disclosed
JP-S59170043-A NOVEL NEMATIC LIQUID CRYSTAL COMPOUND DAINIPPON INK & CHEM INC 1984-09-26 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10799510-B2 Derivatives of 6-substituted triazolopyridazines as Rev-Erb agonists NR1D1, NR1D2, PER2 BACE1 2625/4885ALDH1A1 2864/4885HPGD 2795/4885
US-20170296548-A1 DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS NR1D1, NR1D2, PER2 BACE1 2625/4885ALDH1A1 2864/4885HPGD 2795/4885
US-20150038503-A1 DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS NR1D1, NR1D2, PER2 BACE1 2625/4885ALDH1A1 2864/4885HPGD 2795/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.