Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175775 | 0.87 | PTGS2 (0.33) | — | |
| SCHEMBL6207381 | 0.84 | MARS1 (0.33) | MAPTMEN1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL6203217 | 0.71 | CACNA1B (0.33) | — | |
| SCHEMBL6173810 | 0.67 | MAPT (0.35) | MAPTMEN1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL6173204 | 0.66 | CACNA1B (0.37) | MAPTCYP2C9CYP2C19TP53 | |
| SCHEMBL6172495 | 0.66 | HTR2C (0.36) | MEN1CYP2C9KMT2AKCNA5 | |
| SCHEMBL6174431 | 0.65 | KMT2A (0.39) | MAPTKMT2AROCK2 | |
| SCHEMBL2937503 | 0.63 | ENPP2 (0.44) | KCNA5 | |
| SCHEMBL2938447 | 0.62 | CCR9 (0.38) | MAPTMEN1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL2940197 | 0.62 | PPARD (0.38) | MAPTMEN1CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |