Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARS1 | P56192 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.32 |
| ▸ | LIPE | Q05469 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | FNTA | P49354 | 2/20 | 0.31 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203217 | 0.87 | CACNA1B (0.33) | CACNA1BPTGS2 | |
| SCHEMBL6173288 | 0.84 | MAPT (0.32) | MEN1CYP1A2CYP2D6MAPTCYP2C9 | |
| SCHEMBL6173810 | 0.80 | MAPT (0.35) | MARS1LIPEMEN1CYP1A2CYP2D6 | |
| SCHEMBL2938577 | 0.76 | ENPP2 (0.38) | MARS1CACNA1BFNTAPGGT1BPTGS2 | |
| SCHEMBL6173204 | 0.74 | CACNA1B (0.37) | CACNA1BMAPTCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6175775 | 0.71 | PTGS2 (0.33) | PTGS2 | |
| SCHEMBL6174587 | 0.71 | MAPT (0.37) | MARS1CACNA1BMAPTCYP2C9CYP2C19 | |
| SCHEMBL6172100 | 0.71 | LMNA (0.38) | MARS1CACNA1BFNTAPGGT1BLMNA | |
| SCHEMBL2937776 | 0.67 | ENPP2 (0.36) | CACNA1BLIPEMAPT | |
| SCHEMBL2934288 | 0.67 | CACNA1B (0.39) | CACNA1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |