Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL698881 | 0.89 | AGTR1 (0.60) | AGTR1KDM4ERAB9AALDH1A1KMT2A | |
| SCHEMBL9716675 | 0.86 | LIG1 (0.53) | AGTR1KDM4ERAB9AALDH1A1KMT2A | |
| SCHEMBL9716698 | 0.85 | AGTR1 (0.49) | AGTR1KDM4ERAB9AALDH1A1KMT2A | |
| SCHEMBL10660692 | 0.85 | AGTR1 (0.59) | AGTR1KDM4ERAB9AALDH1A1KMT2A | |
| SCHEMBL8923851 | 0.85 | AKR1C3 (0.57) | AGTR1KDM4ERAB9AALDH1A1KMT2A | |
| SCHEMBL10659074 | 0.81 | KMT2A (0.48) | AGTR1KDM4ERAB9AALDH1A1KMT2A | |
| SCHEMBL6570855 | 0.81 | KMT2A (0.64) | KDM4EALDH1A1KMT2AMEN1HPGD | |
| Benzene SCHEMBL28318261 | 0.78 | AKR1C3 (0.61) | ALDH1A1KMT2AMEN1HPGDNPC1 | |
| SCHEMBL341645 | 0.77 | KDM4E (0.71) | AGTR1KDM4ERAB9AALDH1A1KMT2A | |
| SCHEMBL29620333 | 0.77 | KDM4E (0.71) | AGTR1KDM4ERAB9AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6949543-B2 | Amide derivative | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2005-09-27 | — | — | US | disclosed |
| EP-1340750-B1 | AMIDE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2005-08-17 | — | — | EP | disclosed |
| US-20040034232-A1 | Amide derivative | ASTELLAS PHARMA INC. (JP) | 2004-02-19 | — | — | US | disclosed |
| EP-1340750-A1 | AMIDE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2003-09-03 | — | — | EP | disclosed |
| US-6008235-A | Pyridyl substituted imidazoles | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-28 | — | — | US | disclosed |
| EP-0624159-B1 | PYRIDYL SUBSTITUTED IMIDAZOLES | SMITHKLINE BEECHAM CORP (US) | 1998-11-25 | — | — | EP | disclosed |
| US-5716972-A | Pyridyl substituted imidazoles | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0624159-A4 | PYRIDYL SUBSTITUTED IMIDAZOLES. | SMITHKLINE BEECHAM CORP (US) | 1995-04-12 | — | — | EP | disclosed |
| EP-0624159-A1 | PYRIDYL SUBSTITUTED IMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-11-17 | — | — | EP | disclosed |
| WO-1993014082-A1 | PYRIDYL SUBSTITUTED IMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034232-A1 | Amide derivative | HDAC2, ZC3HAV1, HDAC4 | AGTR1 4243/4885KDM4E 17/4885RAB9A 1475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.