Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.49 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL698881 | 0.89 | AGTR1 (0.60) | AGTR1KDM4ERAB9AMAPTALDH1A1 | |
| SCHEMBL9716675 | 0.86 | LIG1 (0.53) | AGTR1KDM4ERAB9AMAPTALDH1A1 | |
| SCHEMBL6174044 | 0.85 | AGTR1 (0.59) | AGTR1KDM4ERAB9AMAPTALDH1A1 | |
| SCHEMBL10660692 | 0.85 | AGTR1 (0.59) | AGTR1KDM4ERAB9AMAPTALDH1A1 | |
| SCHEMBL8923851 | 0.85 | AKR1C3 (0.57) | AGTR1KDM4ERAB9AALDH1A1KMT2A | |
| SCHEMBL10659074 | 0.81 | KMT2A (0.48) | AGTR1KDM4ERAB9AALDH1A1KMT2A | |
| SCHEMBL6570855 | 0.81 | KMT2A (0.64) | KDM4EMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL1499127 | 0.77 | AGTR1 (0.60) | AGTR1KDM4ERAB9AMAPTALDH1A1 | |
| SCHEMBL341645 | 0.77 | KDM4E (0.71) | AGTR1KDM4ERAB9AMAPTALDH1A1 | |
| SCHEMBL29620333 | 0.77 | KDM4E (0.71) | AGTR1KDM4ERAB9AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0178911-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1992-01-22 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0178911-A2 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1986-04-23 | — | — | EP | disclosed |