Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.64 |
| ▸ | MEN1 | O00255 | 5/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | VNN1 | O95497 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL698881 | 0.85 | AGTR1 (0.60) | KMT2AMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL8923851 | 0.84 | AKR1C3 (0.57) | KMT2AMEN1NPC1ALDH1A1NPSR1 | |
| SCHEMBL9716675 | 0.82 | LIG1 (0.53) | KMT2AMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL10660692 | 0.81 | AGTR1 (0.59) | KMT2AMEN1ALDH1A1MAPTNPSR1 | |
| SCHEMBL9716698 | 0.81 | AGTR1 (0.49) | KMT2AMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL6174044 | 0.81 | AGTR1 (0.59) | KMT2AMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL10541904 | 0.81 | NPC1 (0.61) | KMT2AMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL6610969 | 0.80 | KDM4E (0.54) | KMT2AMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL9002743 | 0.79 | KMT2A (0.54) | KMT2AMEN1NPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9686341 | 0.79 | KMT2A (0.58) | KMT2AMEN1NPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | claimed |
| EP-0838448-B1 | Process for the separation of a mixture of enantiomers | DSM IP ASSETS BV (NL) | 2004-04-21 | — | — | EP | disclosed |
| US-6465684-B2 | DIASTEREOMER COMPLEX OF AT LEAST THREE COMPOUNDS, AT LEAST ONE IS A RESOLVING AGENT IN OPTICALLY ACTIVE FORM, AND AT LEAST ONE IS AN ENANTIOMER IN OPTICALLY ACTIVE FORM; RAPID SEPARATION | DSM N.V. (NL) | 2002-10-15 | — | — | US | disclosed |
| US-20010051747-A1 | Process for the separation of a mixture of enantiomers | DSM N.V. | 2001-12-13 | — | — | US | disclosed |
| US-6235927-B1 | OPTICAL RESOLUTION OF ENANTIOMORPHS OF COMPLEXES | DSM N.V. (NL) | 2001-05-22 | — | — | US | disclosed |
| EP-0838448-A1 | Process for the separation of a mixture of enantiomers | DSM N.V. (NL) | 1998-04-29 | — | — | EP | disclosed |
| EP-0178911-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1992-01-22 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0178911-A2 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1986-04-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010051747-A1 | Process for the separation of a mixture of enantiomers | EPHX2, VKORC1, ALDH1A2 | KMT2A 4602/4885MEN1 2361/4885NPC1 1353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.