Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.56 |
| ▸ | PARP1 | P09874 | 3/20 | 0.54 |
| ▸ | CDC7 | O00311 | 1/20 | 0.53 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 4/20 | 0.49 |
| ▸ | IKBKB | O14920 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22160863 | 0.87 | DHODH (0.59) | DYRK1ACLK4DHODHMEN1PKM | |
| SCHEMBL30832877 | 0.87 | DHODH (0.59) | DYRK1ACLK4DHODHMEN1PKM | |
| SCHEMBL6174339 | 0.86 | TTK (0.52) | JAK2CLK4DHODHKDM4E | |
| SCHEMBL6174664 | 0.83 | KCNA5 (0.49) | DYRK1ADHODHPDE4B | |
| SCHEMBL16277176 | 0.82 | KDM4E (0.58) | JAK2DYRK1ACLK4DHODHMEN1 | |
| SCHEMBL18580116 | 0.81 | TLR8 (0.51) | JAK2PARP1CDC7MAP4K2RIPK2 | |
| SCHEMBL27940845 | 0.79 | PARP1 (0.58) | JAK2PARP1CDC7IKBKBPDE4B | |
| SCHEMBL2991676 | 0.78 | LMNA (0.57) | JAK2PARP1CDC7MAP4K2HTT | |
| SCHEMBL27964788 | 0.78 | RORB (0.68) | JAK2PARP1IKBKBRAB9ASMN1; SMN2 | |
| SCHEMBL27866855 | 0.78 | DYRK1A (0.60) | DYRK1ACLK4HTTKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575918-A2 | SUBSTITUTED BIARYL-4-CARBOXYLIC ACID ARYLAMIDE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2005-09-21 | — | — | EP | claimed |
| WO-2004056774-A2 | SUBSTITUTED BIPHENYL-4-CARBOXYLIC ACID ARYLAMIDE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2004-07-08 | — | — | WO | claimed |