Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 2/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.52 |
| ▸ | DHODH | Q02127 | 3/20 | 0.51 |
| ▸ | RXRA | P19793 | 1/20 | 0.49 |
| ▸ | RXRB | P28702 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | ICMT | O60725 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174210 | 0.86 | JAK2 (0.56) | DHODHKDM4EJAK2CLK4 | |
| SCHEMBL27999916 | 0.85 | PARP10 (0.51) | TTKMAPK8MKNK2MKNK1GAA | |
| SCHEMBL6174664 | 0.81 | KCNA5 (0.49) | DHODHRPS6KB1PDE4AKCNH2 | |
| SCHEMBL29927604 | 0.80 | LRRK2 (0.44) | MKNK2JAK2DYRK3MAP4K4PIM1 | |
| SCHEMBL29927573 | 0.80 | DYRK3 (0.39) | TTKMAPK8DHODHMKNK2NTRK1 | |
| SCHEMBL18580116 | 0.79 | TLR8 (0.51) | DHODHMKNK2MKNK1MAPTKDM4E | |
| SCHEMBL29927534 | 0.77 | JAK2 (0.37) | TTKMAPK8DHODHMKNK2KDM4E | |
| SCHEMBL16277176 | 0.77 | KDM4E (0.58) | DHODHMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL2991676 | 0.76 | LMNA (0.57) | MKNK2MAPTKDM4EJAK2TDP1 | |
| SCHEMBL27964788 | 0.76 | RORB (0.68) | ALDH1A1HPGDJAK2RPS6KB1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575918-A2 | SUBSTITUTED BIARYL-4-CARBOXYLIC ACID ARYLAMIDE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2005-09-21 | — | — | EP | claimed |
| WO-2004056774-A2 | SUBSTITUTED BIPHENYL-4-CARBOXYLIC ACID ARYLAMIDE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2004-07-08 | — | — | WO | claimed |