Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 2/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.40 |
| ▸ | LIPE | Q05469 | 5/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176592 | 0.86 | IGF1R (0.38) | SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2937621 | 0.71 | LIPE (0.42) | CACNA1HCACNA1GCACNA1ILIPELTA4H | |
| SCHEMBL6174328 | 0.69 | GAA (0.41) | CACNA1HCACNA1GCACNA1ILIPELTA4H | |
| SCHEMBL2937313 | 0.68 | CACNA1G (0.41) | CACNA1HCACNA1GCACNA1ILIPELTA4H | |
| SCHEMBL2932740 | 0.67 | CACNA1G (0.41) | CACNA1HCACNA1GCACNA1ILIPELTA4H | |
| SCHEMBL2939425 | 0.67 | IGF1R (0.44) | CACNA1HCACNA1GCACNA1ILIPEPOLB | |
| SCHEMBL6173573 | 0.65 | CACNA1H (0.41) | CACNA1HCACNA1GCACNA1ICXCR3ALDH1A1 | |
| SCHEMBL6173172 | 0.65 | LMNA (0.41) | KCNH2L3MBTL1SMN1; SMN2LMNAFLT1 | |
| SCHEMBL6173353 | 0.65 | LMNA (0.45) | LIPEPDE2AKCNH2POLBL3MBTL1 | |
| SCHEMBL6173781 | 0.65 | LMNA (0.43) | LIPEKCNH2POLBL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |