Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | KDR | P35968 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.64 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5215050 | 0.88 | KMT2A (0.59) | TSHRSMN1; SMN2KMT2ACYP1A2CYP2C9 | |
| SCHEMBL4653584 | 0.86 | SMN1; SMN2 (1.00) | TSHRSMN1; SMN2KMT2ACYP1A2CYP2C9 | |
| SCHEMBL10294799 | 0.84 | KMT2A (0.78) | TSHRSMN1; SMN2KMT2AHTTLMNA | |
| SCHEMBL22983352 | 0.82 | ALDH1A1 (0.84) | TSHRSMN1; SMN2KMT2ACYP1A2CYP2C9 | |
| SCHEMBL27989071 | 0.82 | KMT2A (0.62) | TSHRSMN1; SMN2KMT2AHTTLMNA | |
| SCHEMBL29927602 | 0.81 | TSHR (0.62) | TSHRSMN1; SMN2KMT2ACYP1A2CYP2C9 | |
| SCHEMBL29927042 | 0.81 | TSHR (0.61) | TSHRSMN1; SMN2KMT2ACYP1A2CYP2C9 | |
| SCHEMBL24933360 | 0.81 | RAB9A (0.73) | TSHRSMN1; SMN2KMT2ACYP1A2CYP2C9 | |
| SCHEMBL6174665 | 0.80 | KMT2A (0.73) | TSHRSMN1; SMN2KMT2ACYP1A2CYP2C9 | |
| SCHEMBL259177 | 0.79 | TDP1 (0.78) | TSHRSMN1; SMN2KMT2ACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575918-A2 | SUBSTITUTED BIARYL-4-CARBOXYLIC ACID ARYLAMIDE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2005-09-21 | — | — | EP | claimed |
| WO-2004056774-A2 | SUBSTITUTED BIPHENYL-4-CARBOXYLIC ACID ARYLAMIDE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2004-07-08 | — | — | WO | claimed |