Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 11/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175954 | 0.87 | HSD11B1 (0.48) | HSD11B1CYP2C9ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL6174534 | 0.77 | CYP2C9 (0.39) | HSD11B1CYP2C9ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL6176108 | 0.76 | CYP2C9 (0.38) | HSD11B1CYP2C9ALDH1A1HTTTSHR | |
| SCHEMBL6173671 | 0.74 | HSD11B1 (0.52) | HSD11B1CYP2C9 | |
| SCHEMBL6175182 | 0.73 | ALDH1A1 (0.46) | HSD11B1CYP2C9ALDH1A1GAAHTT | |
| SCHEMBL6175910 | 0.70 | HSD11B1 (0.44) | HSD11B1CYP2C9 | |
| SCHEMBL6174556 | 0.67 | OPRD1 (0.44) | CYP2C9 | |
| SCHEMBL6175172 | 0.64 | LDHA (0.38) | HSD11B1CYP2C9ALDH1A1 | |
| SCHEMBL7489755 | 0.64 | CYP2C9 (0.42) | HSD11B1CYP2C9ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL6174510 | 0.63 | OPRD1 (0.58) | CYP2C9GAATSHRTAAR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203770-B1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | UPJOHN CO (US) | 2005-03-09 | — | — | EP | claimed |
| EP-0668860-B1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | UPJOHN CO (US) | 2002-09-11 | — | — | EP | claimed |