Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 3/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173713 | 0.88 | PTGES (0.38) | ALDH1A1NAMPTADRB3ALOX12ADRB2 | |
| SCHEMBL6174502 | 0.88 | PDE4B (0.42) | SMN1; SMN2LMNAALDH1A1HTTNPSR1 | |
| SCHEMBL7403401 | 0.87 | MLNR (0.33) | NAMPTADRB3 | |
| SCHEMBL7440280 | 0.87 | NAMPT (0.40) | NAMPTADRB3ADRB2ADRB1KMT2A | |
| SCHEMBL7395313 | 0.87 | MLNR (0.37) | LMNANAMPTADRB3GAATSHR | |
| SCHEMBL6174303 | 0.86 | ITGA1 (0.40) | SMN1; SMN2HSD17B2ALOX12MMP1KMT2A | |
| SCHEMBL7482607 | 0.86 | ALDH1A1 (0.40) | LMNAALDH1A1HTTKMT2AGAA | |
| SCHEMBL7439445 | 0.86 | LIMK2 (0.36) | ALDH1A1NAMPTHTR6 | |
| SCHEMBL7440371 | 0.86 | HDAC1 (0.37) | SMN1; SMN2ALDH1A1HTTNAMPTALOX12 | |
| SCHEMBL7447436 | 0.86 | LIMK2 (0.37) | HSD17B2ALOX12KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203770-B1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | UPJOHN CO (US) | 2005-03-09 | — | — | EP | claimed |
| EP-0668860-B1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | UPJOHN CO (US) | 2002-09-11 | — | — | EP | claimed |