Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 14/20 | 0.59 |
| ▸ | ITGAV | P06756 | 13/20 | 0.59 |
| ▸ | ITGB1 | P05556 | 8/20 | 0.59 |
| ▸ | ITGB6 | P18564 | 4/20 | 0.59 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.59 |
| ▸ | ITGA5 | P08648 | 5/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | MDM4 | O15151 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178117 | 0.87 | ITGB3 (0.64) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL6178761 | 0.87 | ITGB3 (0.64) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL6179695 | 0.87 | ITGB3 (0.64) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL6177908 | 0.74 | ITGB3 (1.00) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL6175356 | 0.70 | ITGB3 (0.64) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL6177744 | 0.66 | ITGB3 (0.46) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL5870544 | 0.66 | ACACB (0.60) | — | |
| SCHEMBL6177264 | 0.65 | ITGB3 (0.55) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL6177062 | 0.65 | LDHA (0.64) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL13643128 | 0.65 | MAOB (0.64) | ITGB3ITGAVITGB1ITGB6ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1061921-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1061921-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999045927-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-09-16 | — | — | WO | disclosed |