Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172376 | 0.88 | ALDH1A1 (0.37) | ALDH1A1LMNACYP3A4GAACYP2C9 | |
| SCHEMBL6171339 | 0.87 | IGF1R (0.39) | IGF1RALDH1A1LMNAARCYP3A4 | |
| SCHEMBL6174624 | 0.86 | IGF1R (0.39) | IGF1RALDH1A1LMNA | |
| SCHEMBL6172497 | 0.85 | IGF1R (0.37) | IGF1RALDH1A1LMNAARCYP3A4 | |
| SCHEMBL6175145 | 0.84 | ALDH1A1 (0.40) | IGF1RALDH1A1LMNACYP3A4GAA | |
| SCHEMBL6173058 | 0.83 | IGF1R (0.36) | IGF1RALDH1A1LMNAARCYP3A4 | |
| SCHEMBL6172914 | 0.81 | IGF1R (0.38) | IGF1RLMNAARCYP3A4GAA | |
| SCHEMBL6176124 | 0.81 | IGF1R (0.42) | IGF1RLMNAARTRPV3KMT2A | |
| SCHEMBL6173852 | 0.80 | IGF1R (0.37) | IGF1RARTRPV3KMT2AMAPT | |
| SCHEMBL6201343 | 0.80 | PTGS2 (0.40) | IGF1RLMNAARCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |