Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK7 | Q13164 | 3/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | LIPE | Q05469 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173052 | 0.93 | EPHX2 (0.36) | EPHX2KCNA5LIPELMNAHRH3 | |
| SCHEMBL6251397 | 0.91 | EPHX2 (0.39) | EPHX2ALDH1A1MAPK7KCNA5LIPE | |
| SCHEMBL6175321 | 0.91 | KCNA5 (0.41) | ALDH1A1KCNA5TP53MDM2LIPE | |
| SCHEMBL6170501 | 0.86 | LMNA (0.42) | EPHX2LIPELMNA | |
| SCHEMBL6176359 | 0.85 | LMNA (0.39) | LIPELMNA | |
| SCHEMBL6177656 | 0.85 | LMNA (0.37) | ALDH1A1MAPK7LMNAABL1 | |
| SCHEMBL6174458 | 0.83 | SLC5A1 (0.40) | ALDH1A1LIPELMNA | |
| SCHEMBL6173353 | 0.82 | LMNA (0.45) | ALDH1A1TP53LIPELMNA | |
| SCHEMBL6173172 | 0.80 | LMNA (0.41) | TP53LMNAABL1 | |
| SCHEMBL6173346 | 0.80 | EPHX2 (0.40) | EPHX2MAPK7KCNA5LIPELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |