Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A1 | P13866 | 1/20 | 0.40 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 7/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.34 |
| ▸ | LIPE | Q05469 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170501 | 0.89 | LMNA (0.42) | MAPTCXCR3LMNAPOLBL3MBTL1 | |
| SCHEMBL6176359 | 0.88 | LMNA (0.39) | MAPTCXCR3LMNAPOLBL3MBTL1 | |
| SCHEMBL6174658 | 0.87 | RXFP1 (0.34) | MAPTLMNAPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL6173353 | 0.87 | LMNA (0.45) | CXCR3LMNAPOLBL3MBTL1LIPE | |
| SCHEMBL6173052 | 0.84 | EPHX2 (0.36) | CXCR3LMNAPOLBL3MBTL1LIPE | |
| SCHEMBL6173172 | 0.83 | LMNA (0.41) | MAPTLMNAL3MBTL1 | |
| SCHEMBL6175577 | 0.83 | EPHX2 (0.40) | LMNALIPEALDH1A1 | |
| SCHEMBL6251397 | 0.82 | EPHX2 (0.39) | LMNALIPEALDH1A1PKM | |
| SCHEMBL6173698 | 0.82 | LMNA (0.42) | CXCR3LMNAPOLBL3MBTL1CYP3A4 | |
| SCHEMBL6173298 | 0.82 | LMNA (0.39) | MAPTCXCR3LMNAPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |