Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | ALDH3A1 | P30838 | 6/20 | 0.58 |
| ▸ | ALDH2 | P05091 | 4/20 | 0.58 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 3/20 | 0.56 |
| ▸ | CES1 | P23141 | 2/20 | 0.56 |
| ▸ | PARK7 | Q99497 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176718 | 0.89 | ALDH1A1 (0.45) | ALDH1A1ALDH3A1ALDH2CUL4AACHE | |
| SCHEMBL21001752 | 0.84 | ALDH1A1 (0.65) | ALDH1A1ALDH3A1ALDH2CUL4AACHE | |
| SCHEMBL10678916 | 0.83 | ALDH1A1 (0.58) | ALDH1A1ALDH3A1ALDH2CUL4AACHE | |
| SCHEMBL6179832 | 0.83 | ALDH3A1 (0.58) | ALDH1A1ALDH3A1ALDH2PARK7 | |
| SCHEMBL30892351 | 0.83 | ALDH3A1 (0.58) | ALDH1A1ALDH3A1ALDH2PARK7 | |
| SCHEMBL29220077 | 0.82 | ALDH1A1 (0.67) | ALDH1A1ALDH3A1ALDH2CUL4AACHE | |
| SCHEMBL22667286 | 0.81 | CUL4A (0.68) | ALDH1A1ALDH3A1ALDH2CUL4AACHE | |
| SCHEMBL30403461 | 0.81 | CUL4A (0.68) | ALDH1A1ALDH3A1ALDH2CUL4AACHE | |
| SCHEMBL29011253 | 0.80 | ALDH1A1 (0.63) | ALDH1A1ALDH3A1ALDH2CUL4AACHE | |
| SCHEMBL28606638 | 0.79 | CES1 (0.65) | ALDH1A1ALDH3A1ALDH2CUL4AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105376-B1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMA (JP) | 2005-02-09 | — | — | EP | disclosed |
| CN-1161333-C | Oxindole derivatives as growth hormone releasers | ס����ҩ��ʽ���� | 2004-08-11 | — | — | CN | disclosed |
| US-6576656-B1 | Such as 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-carbamoyl-3-hydroxy-3-(2 -chlorophenyl)oxindole; growth hormone releaser | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2003-06-10 | — | — | US | disclosed |