SCHEMBL6176718

SCHEMBL6176718

CCN(CC)CCN1C(=O)C(=O)c2ccc(Br)cc21

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.45
ALDH2 P05091 3/20 0.45
ALDH3A1 P30838 3/20 0.45
CUL4A Q13619 1/20 0.44
KDM4E B2RXH2 1/20 0.44
CES1 P23141 5/20 0.43
BCHE P06276 2/20 0.43
ACHE P22303 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
MAOB P27338 1/20 0.41
MEN1 O00255 1/20 0.41
CYP1A2 P05177 1/20 0.41
POLB P06746 1/20 0.41
TNNI3 P19429 1/20 0.41
MAPK1 P28482 1/20 0.41
STAT6 P42226 1/20 0.41
TNNT2 P45379 1/20 0.41
TNNC1 P63316 1/20 0.41
KMT2A Q03164 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6176074 0.89 ALDH1A1 (0.58) ALDH1A1ALDH2ALDH3A1CUL4AKDM4E
SCHEMBL16075218 0.86 ALDH1A1 (0.47) ALDH1A1ALDH2ALDH3A1CUL4AKDM4E
SCHEMBL28417115 0.81 ALDH1A1 (0.57) ALDH1A1ALDH2ALDH3A1CUL4ACES1
SCHEMBL16075217 0.81 TERT (0.54) ALDH1A1ALDH2ALDH3A1CUL4AKDM4E
SCHEMBL28026697 0.81 PARK7 (0.53) ALDH1A1ALDH2ALDH3A1CUL4ACES1
SCHEMBL28417285 0.79 CES1 (0.65) ALDH1A1ALDH2ALDH3A1CUL4ACES1
SCHEMBL16064397 0.77 ALDH1A1 (0.47) ALDH1A1ALDH2ALDH3A1CUL4ACES1
SCHEMBL16064931 0.77 ALDH1A1 (0.47) ALDH1A1ALDH2ALDH3A1CUL4ACES1
SCHEMBL30892351 0.75 ALDH3A1 (0.58) ALDH1A1ALDH2ALDH3A1CHRM5
SCHEMBL6179832 0.75 ALDH3A1 (0.58) ALDH1A1ALDH2ALDH3A1CHRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1105376-B1 OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS SUMITOMO PHARMA (JP) 2005-02-09 EP disclosed
CN-1161333-C Oxindole derivatives as growth hormone releasers ס����ҩ��ʽ���� 2004-08-11 CN disclosed
US-6576656-B1 Such as 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-carbamoyl-3-hydroxy-3-(2 -chlorophenyl)oxindole; growth hormone releaser SUMITOMO PHARMACEUTICALS CO., LTD. (JP) 2003-06-10 US disclosed
CN-1313853-A Oxindole derivatives as growth hormone releasers SUMITOMO PHARMA (JP) 2001-09-19 CN disclosed
EP-1105376-A1 OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2001-06-13 EP disclosed
WO-2000010975-A1 OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS SUMITOMO PHARMACEUTICALS CO., LTD. (JP) 2000-03-02 WO disclosed