Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.49 |
| ▸ | STAT6 | P42226 | 1/20 | 0.49 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.49 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | CTRC | Q99895 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.44 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.44 |
| ▸ | GHSR | Q92847 | 1/20 | 0.44 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28036579 | 0.81 | ALDH1A1 (0.54) | KMT2AMEN1MAPK1POLBNPSR1 | |
| SCHEMBL6180021 | 0.78 | GHSR (0.47) | KMT2AMEN1MAPK1POLBNPSR1 | |
| SCHEMBL6176074 | 0.75 | ALDH1A1 (0.58) | ALDH1A1ALDH3A1PARK7KDM4EBCHE | |
| SCHEMBL6176718 | 0.75 | ALDH1A1 (0.45) | KMT2AMEN1MAPK1POLBNPSR1 | |
| SCHEMBL929729 | 0.74 | MAOB (0.77) | KMT2AMEN1MAPK1POLBNPSR1 | |
| SCHEMBL18954749 | 0.72 | ALDH1A1 (0.57) | MAPK1NPSR1CYP1A2ALDH1A1ALDH3A1 | |
| SCHEMBL3778381 | 0.72 | ALDH1A1 (0.65) | KMT2AMEN1MAPK1POLBCTRC | |
| SCHEMBL30291060 | 0.72 | ALDH1A1 (0.65) | KMT2AMEN1MAPK1POLBCTRC | |
| Isatin SCHEMBL6180239 | 0.71 | ALDH1A1 (0.44) | KMT2AMEN1MAPK1POLBNPSR1 | |
| SCHEMBL6263721 | 0.71 | POLB (0.76) | KMT2AMEN1MAPK1POLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105376-B1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMA (JP) | 2005-02-09 | — | — | EP | disclosed |
| CN-1161333-C | Oxindole derivatives as growth hormone releasers | ס����ҩ��ʽ���� | 2004-08-11 | — | — | CN | disclosed |
| US-6576656-B1 | Such as 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-carbamoyl-3-hydroxy-3-(2 -chlorophenyl)oxindole; growth hormone releaser | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2003-06-10 | — | — | US | disclosed |
| EP-1105376-A1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000010975-A1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2000-03-02 | — | — | WO | disclosed |