Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | ALDH2 | P05091 | 4/20 | 0.55 |
| ▸ | ALDH3A1 | P30838 | 4/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | GHSR | Q92847 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30892351 | 0.92 | ALDH3A1 (0.58) | ALDH1A1ALDH2ALDH3A1HTR1ADRD3 | |
| SCHEMBL6179832 | 0.92 | ALDH3A1 (0.58) | ALDH1A1ALDH2ALDH3A1HTR1ADRD3 | |
| SCHEMBL16046979 | 0.85 | ALDH1A1 (0.62) | ALDH1A1ALDH2ALDH3A1MEN1KMT2A | |
| SCHEMBL16366714 | 0.83 | ALDH1A1 (0.64) | ALDH1A1ALDH2ALDH3A1MEN1KMT2A | |
| SCHEMBL28533366 | 0.83 | ALDH3A1 (0.67) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL3025055 | 0.82 | CES1 (0.65) | ALDH1A1ALDH2ALDH3A1MEN1KMT2A | |
| SCHEMBL29281825 | 0.82 | UCHL3 (0.45) | ALDH1A1ALDH2ALDH3A1HTR1ADRD3 | |
| SCHEMBL29281830 | 0.82 | UCHL3 (0.45) | ALDH1A1ALDH2ALDH3A1HTR1ADRD3 | |
| SCHEMBL30892344 | 0.82 | UCHL3 (0.45) | ALDH1A1ALDH2ALDH3A1HTR1ADRD3 | |
| SCHEMBL29011260 | 0.82 | ALDH3A1 (0.62) | ALDH1A1ALDH2ALDH3A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105376-B1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMA (JP) | 2005-02-09 | — | — | EP | disclosed |
| US-6576656-B1 | Such as 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-carbamoyl-3-hydroxy-3-(2 -chlorophenyl)oxindole; growth hormone releaser | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2003-06-10 | — | — | US | disclosed |