Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.35 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ATP4A | P20648 | 1/20 | 0.33 |
| ▸ | ATP4B | P51164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18396472 | 0.86 | SLC6A2 (0.38) | ADRA2AADRA2BADRA2CHTR1AALDH1A1 | |
| SCHEMBL31281851 | 0.86 | SLC6A2 (0.38) | ADRA2AADRA2BADRA2CHTR1AALDH1A1 | |
| SCHEMBL9621391 | 0.80 | TAAR1 (0.40) | TAAR1HTR1AAOC3MTNR1AMTNR1B | |
| SCHEMBL26637586 | 0.80 | ADRA2A (0.35) | TAAR1ADRA2AADRA2BADRA2CHTR1A | |
| SCHEMBL8053601 | 0.77 | IRAK4 (0.44) | TAAR1ADRA2AADRA2BADRA2CHTR1A | |
| SCHEMBL7438547 | 0.75 | NPSR1 (0.36) | TAAR1AOC3MTNR1AMTNR1BSIGMAR1 | |
| SCHEMBL9843615 | 0.75 | ADRA2C (0.52) | ADRA2AADRA2BADRA2CHTR1AADRB2 | |
| SCHEMBL8036410 | 0.74 | ADRB2 (0.49) | ADRA2CHTR1AADRB2ADRB1ALDH1A1 | |
| SCHEMBL852646 | 0.74 | TAAR1 (0.64) | TAAR1AOC3MTNR1AMTNR1BSIGMAR1 | |
| SCHEMBL29474956 | 0.74 | TAAR1 (0.64) | TAAR1AOC3MTNR1AMTNR1BSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1061921-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1061921-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999045927-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-09-16 | — | — | WO | disclosed |