Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 9/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | RGS12 | O14924 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28480773 | 0.84 | KMT2A (0.52) | KMT2AMAPTSMN1; SMN2POLBLMNA | |
| SCHEMBL25200788 | 0.81 | HSPB1 (0.59) | HSPB1KMT2AMAPTSMN1; SMN2POLB | |
| SCHEMBL17571121 | 0.81 | HSPB1 (0.59) | HSPB1KMT2AMAPTSMN1; SMN2POLB | |
| SCHEMBL8827695 | 0.81 | MAPT (0.49) | HSPB1KMT2AMAPTSMN1; SMN2POLB | |
| SCHEMBL1980276 | 0.78 | HSPB1 (0.56) | HSPB1KMT2AMAPTSMN1; SMN2POLB | |
| SCHEMBL1978695 | 0.78 | KEAP1 (0.59) | HSPB1KMT2AMAPTSMN1; SMN2POLB | |
| SCHEMBL16792542 | 0.78 | HSPB1 (0.75) | HSPB1KMT2AMAPTSMN1; SMN2POLB | |
| SCHEMBL6176183 | 0.78 | KEAP1 (0.58) | KMT2AMAPTSMN1; SMN2POLBLMNA | |
| SCHEMBL25184221 | 0.78 | KMT2A (0.60) | HSPB1KMT2AMAPTSMN1; SMN2POLB | |
| SCHEMBL11201076 | 0.77 | LMNA (0.46) | KMT2AMAPTSMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066261-B1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMA CO LTD (JP) | 2005-11-23 | — | — | EP | disclosed |
| US-6511995-B1 | Inhibits collagen synthesis, which is useful for prophylaxis or treatment of fibrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1066261-A1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999048871-A1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1999-09-30 | — | — | WO | disclosed |