SCHEMBL618025

SCHEMBL618025

CCC(=O)N1CCC(COc2cccc3nc(C)c(C(=O)O)c(N)c23)CC1

nearest known ligand 0.50

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
DCPS Q96C86 14/20 0.50
DHFR P00374 2/20 0.42
CYP2D6 P10635 1/20 0.42
RBP4 P02753 1/20 0.39
TTR P02766 1/20 0.39
P2RX3 P56373 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL620792 0.93 DCPS (0.49) DCPSDHFRCYP2D6
SCHEMBL621330 0.91 DCPS (0.49) DCPSDHFRCYP2D6
SCHEMBL10257622 0.88 DCPS (0.49) DCPSDHFRCYP2D6RBP4TTR
SCHEMBL619357 0.88 DCPS (0.49) DCPSDHFRCYP2D6
SCHEMBL618750 0.86 DCPS (0.48) DCPSDHFRCYP2D6
SCHEMBL621384 0.86 DCPS (0.48) DCPSDHFRCYP2D6
SCHEMBL15677269 0.86 DCPS (0.47) DCPSDHFRCYP2D6
SCHEMBL27102670 0.86 DCPS (0.60) DCPSDHFRRBP4TTR
SCHEMBL619531 0.85 DCPS (0.47) DCPSDHFRCYP2D6
Hydrochloric Acid SCHEMBL619258 0.85 DCPS (0.47) DCPSDHFRCYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2603098-B1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER FIRMENICH INCORPORATED (US) 2025-08-06 EP disclosed
US-20240065302-A1 SWEETENER COMPOSITIONS COMPRISING MOGROSIDES AND USES THEREOF FIRMENICH INCORPORATED 2024-02-29 US disclosed
US-20240065302-A1 SWEETENER COMPOSITIONS COMPRISING MOGROSIDES AND USES THEREOF FIRMENICH INCORPORATED 2024-02-29 US disclosed
US-11129397-B2 Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer FIREMENICH INCORPORATED (US) 2021-09-28 US disclosed
US-11129397-B2 Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer FIREMENICH INCORPORATED (US) 2021-09-28 US disclosed
CN-106107406-B Methods of improving the stability of sweetness enhancers and compositions comprising stable sweetness enhancers 弗门尼舍公司 2020-06-09 CN disclosed
US-20190208802-A1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER FIRMENICH INCORPORATED 2019-07-11 US disclosed
US-20190208802-A1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER FIRMENICH INCORPORATED 2019-07-11 US disclosed
US-10244779-B2 Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer SENOMYX, INC. (US) 2019-04-02 US disclosed
US-10244779-B2 Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer SENOMYX, INC. (US) 2019-04-02 US disclosed
US-8815956-B2 Sweet flavor modifier SENOMYX, INC. (US) 2014-08-26 US disclosed
EP-2742026-A1 SWEET FLAVOR MODIFIER Senomyx, Inc. (US) 2014-06-18 EP disclosed
WO-2013158928-A2 CHEMOSENSORY RECEPTOR LIGAND-BASED THERAPIES ELCELYX THERAPEUTICS, INC. (US) 2013-10-24 WO disclosed
WO-2013025560-A1 SWEET FLAVOR MODIFIER SENOMYX, INC. (US) 2013-02-21 WO disclosed
WO-2013025560-A1 SWEET FLAVOR MODIFIER SENOMYX, INC. (US) 2013-02-21 WO disclosed
US-20130041046-A1 SWEET FLAVOR MODIFIER SENOMYX, INC. (US) 2013-02-14 US disclosed
US-20130041046-A1 SWEET FLAVOR MODIFIER SENOMYX, INC. (US) 2013-02-14 US disclosed
US-20120041078-A1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER SENOMYX, INC. (US) 2012-02-16 US disclosed
US-20120041078-A1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER SENOMYX, INC. (US) 2012-02-16 US disclosed
WO-2012021837-A2 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER SENOMYX, INC. (US) 2012-02-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10244779-B2 Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer TFEB, TREH, SLC2A8 DCPS 919/4885DHFR 2350/4885CYP2D6 4715/4885
US-20120041078-A1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER TFEB, TREH, SLC2A8 DCPS 919/4885DHFR 2350/4885CYP2D6 4715/4885
US-20130041046-A1 SWEET FLAVOR MODIFIER TAS2R5, TAS2R10, TAS2R50 DCPS 1074/4885DHFR 2252/4885CYP2D6 3170/4885
US-11129397-B2 Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer TFEB, TREH, SLC2A8 DCPS 919/4885DHFR 2350/4885CYP2D6 4715/4885
US-20190208802-A1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER TFEB, TREH, SLC2A8 DCPS 919/4885DHFR 2350/4885CYP2D6 4715/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.