Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177254 | 0.83 | LMNA (0.79) | LMNAALDH1A1NPC1RAB9ATRPA1 | |
| SCHEMBL6177256 | 0.83 | LMNA (0.79) | LMNAALDH1A1NPC1RAB9ATRPA1 | |
| SCHEMBL6178979 | 0.81 | PSEN1 (0.57) | LMNAALDH1A1TRPA1GAAPOLB | |
| SCHEMBL6180434 | 0.80 | TRPA1 (0.47) | LMNATRPA1GAA | |
| SCHEMBL3367330 | 0.80 | SMN1; SMN2 (0.49) | LMNAALDH1A1NPC1RAB9AGAA | |
| SCHEMBL6179184 | 0.79 | TRPA1 (0.57) | LMNATRPA1GAAMAPK1KDM4E | |
| SCHEMBL6178702 | 0.79 | LMNA (0.79) | LMNAALDH1A1TRPA1GAAMEN1 | |
| SCHEMBL6178698 | 0.79 | LMNA (0.79) | LMNAALDH1A1TRPA1GAAMEN1 | |
| SCHEMBL6180284 | 0.79 | LMNA (0.79) | LMNAALDH1A1TRPA1GAAKDM4E | |
| SCHEMBL6180279 | 0.79 | LMNA (0.79) | LMNAALDH1A1TRPA1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165510-B1 | 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | EP | claimed |