Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKAR | P32238 | 2/20 | 0.44 |
| ▸ | CCKBR | P32239 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLQ | O75417 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6179501 | 0.86 | CCKAR (0.45) | CCKARCCKBRPOLBDRD4ALDH1A1 | |
| SCHEMBL6181562 | 0.83 | POLB (0.48) | CCKARCCKBRPOLBDRD4GAA | |
| SCHEMBL6178348 | 0.78 | SCN9A (0.47) | CCKARCCKBRPOLB | |
| SCHEMBL4703310 | 0.75 | CYP1A2 (0.39) | — | |
| SCHEMBL8552734 | 0.73 | POLB (0.44) | CCKARCCKBRPOLBALDH1A1POLQ | |
| SCHEMBL4064792 | 0.72 | AADAT (0.54) | POLB | |
| SCHEMBL14373863 | 0.72 | POLQ (0.46) | DRD4ALDH1A1GAAAPOBEC3AAPOBEC3G | |
| SCHEMBL9573635 | 0.71 | GABRP (0.56) | CCKARCCKBRPOLB | |
| SCHEMBL3455174 | 0.70 | DRD4 (0.59) | DRD4ALDH1A1GAAAPOBEC3AAPOBEC3G | |
| SCHEMBL4424732 | 0.69 | GABRP (0.44) | CCKBRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0945445-B9 | 1,5-BENZODIAZEPINE DERIVATIVES | ZERIA PHARM CO LTD (JP) | 2005-12-28 | — | — | EP | disclosed |
| EP-0945445-B1 | 1,5-BENZODIAZEPINE DERIVATIVES | ZERIA PHARM CO LTD (JP) | 2003-09-03 | — | — | EP | disclosed |
| US-6239131-B1 | WHICH HAVE GASTRIN AND/OR CCK-B (CHOLECYSTOKININ-B) RECEPTOR ANTAGONISM, USEFUL AS REMEDIES FOR GASTRIC ULCER AND GASTROINTESTINAL MOVEMENT DISORDER. | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 2001-05-29 | — | — | US | disclosed |
| EP-0945445-A1 | 1,5-BENZODIAZEPINE DERIVATIVES | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1999-09-29 | — | — | EP | disclosed |