Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLQ | O75417 | 1/20 | 0.39 |
| ▸ | CCKAR | P32238 | 2/20 | 0.39 |
| ▸ | CCKBR | P32239 | 2/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | GABRE | P78334 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9573635 | 0.87 | GABRP (0.56) | POLBTP53CCKARCCKBRGABRP | |
| SCHEMBL8796363 | 0.86 | ALDH1A1 (0.62) | ALDH1A1LMNATP53CCKARCCKBR | |
| Bromide SCHEMBL8795194 | 0.85 | ALDH1A1 (0.61) | ALDH1A1CCKARCCKBR | |
| SCHEMBL8550878 | 0.85 | CCKBR (0.45) | POLBALDH1A1CCKARCCKBR | |
| SCHEMBL9573583 | 0.84 | CCKBR (0.47) | ALDH1A1CCKARCCKBRGABRPGABRD | |
| SCHEMBL8553824 | 0.80 | POLB (0.41) | POLBALDH1A1LMNATP53 | |
| SCHEMBL8554660 | 0.79 | CCKAR (0.47) | CCKARCCKBR | |
| Benzyl Carbamate SCHEMBL8093423 | 0.78 | ALDH1A1 (0.52) | ALDH1A1CCKARCCKBR | |
| SCHEMBL8554316 | 0.76 | OXTR (0.41) | ALDH1A1CCKARCCKBR | |
| SCHEMBL8555479 | 0.75 | CCKBR (0.43) | POLBLMNATP53CCKARCCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672037-B1 | 1,4-BENZODIAZEPINE DERIVATIVES AND THEIR USE AS CCK-MODULATORS | GLAXO GROUP LTD (GB) | 1998-07-08 | — | — | EP | disclosed |
| US-5569654-A | ADMINISTERING AS ANTAGONISTS OF GASTRIN AND CHOLECYSTOKININ | GLAXO GROUP LIMITED (GB) | 1996-10-29 | — | — | US | disclosed |