Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4576853 | 0.80 | DRD2 (0.50) | DRD2SLC18A3HRH1HRH3KDM1A | |
| SCHEMBL8096432 | 0.77 | DRD2 (0.68) | DRD2SLC18A3HRH3KDM1ACARM1 | |
| SCHEMBL81936 | 0.76 | DRD2 (0.55) | DRD2SLC18A3HRH3KDM1ATLR9 | |
| SCHEMBL14320360 | 0.74 | DRD2 (0.54) | DRD2SLC18A3HRH1KDM1ATLR9 | |
| SCHEMBL22804312 | 0.74 | DRD2 (0.54) | DRD2SLC18A3KDM1ACARM1PRMT6 | |
| SCHEMBL7534840 | 0.72 | DRD2 (0.69) | DRD2CARM1PRMT6 | |
| SCHEMBL22804730 | 0.71 | DRD2 (0.50) | DRD2SLC18A3HRH1HRH3KDM1A | |
| SCHEMBL3145598 | 0.71 | RAB9A (0.61) | HRH1HRH3 | |
| SCHEMBL3149207 | 0.70 | LTA4H (0.71) | HRH1HRH3HRH2 | |
| SCHEMBL1305330 | 0.70 | SLC18A3 (0.58) | DRD2SLC18A3HRH1HRH3KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537074-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA INC. (CA) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004022526-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2004-03-18 | — | — | WO | disclosed |