Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5802150 | 0.80 | HTR6 (0.47) | — | |
| SCHEMBL1340908 | 0.70 | ALPL (0.36) | KDM4CALPLALPIUSP2MEN1 | |
| SCHEMBL7791634 | 0.68 | HTR3A (0.44) | KDM4C | |
| SCHEMBL5799245 | 0.68 | ESR1 (0.37) | KDM4C | |
| SCHEMBL15818455 | 0.68 | KDM4C (0.43) | KDM4CALPLALPIUSP2MEN1 | |
| SCHEMBL25675893 | 0.68 | KDM4C (0.43) | KDM4CALPLALPIUSP2MEN1 | |
| SCHEMBL21655317 | 0.68 | KDM4C (0.43) | KDM4CALPLALPIUSP2MEN1 | |
| SCHEMBL5798547 | 0.66 | CYP19A1 (0.44) | — | |
| SCHEMBL5798616 | 0.66 | ESR1 (0.37) | HCRTR1 | |
| SCHEMBL5172771 | 0.65 | KDM4C (0.44) | KDM4CALPLALPIUSP2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507767-A1 | 4-SUBSTITUTED IMIDAZOLE-2-THIONES AND IMIDAZOL-2-ONES AS AGONISTS OF THE ALPHA-2B AND ALPHA-2C ADRENERGIC RECEPTORS | Allergan, Inc. (US) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003099795-A1 | 4-SUBSTITUTED IMIDAZOLE-2-THIONES AND IMIDAZOL-2-ONES AS AGONISTS OF THE ALPHA-2B AND ALPHA-2C ADRENERGIC RECEPTORS | ALLERGAN, INC. (US) | 2003-12-04 | — | — | WO | disclosed |