Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8762387 | 0.92 | NR4A1 (0.58) | SMN1; SMN2NR4A1ALDH1A1CYP3A4TDP1 | |
| SCHEMBL486670 | 0.89 | NR4A1 (0.61) | SMN1; SMN2NR4A1ALDH1A1CYP3A4TDP1 | |
| SCHEMBL29568160 | 0.87 | ALDH1A1 (0.59) | SMN1; SMN2ALDH1A1CYP3A4TDP1MAPK1 | |
| SCHEMBL91981 | 0.87 | ALDH1A1 (0.59) | SMN1; SMN2ALDH1A1CYP3A4TDP1MAPK1 | |
| SCHEMBL10350063 | 0.86 | ALDH1A1 (0.61) | SMN1; SMN2NR4A1ALDH1A1CYP3A4TDP1 | |
| SCHEMBL10353183 | 0.86 | ALDH1A1 (0.58) | SMN1; SMN2NR4A1LTA4HALDH1A1CYP3A4 | |
| SCHEMBL7185516 | 0.86 | ALDH1A1 (0.61) | SMN1; SMN2NR4A1ALDH1A1CYP3A4TDP1 | |
| SCHEMBL31457310 | 0.86 | ALDH1A1 (0.61) | SMN1; SMN2NR4A1ALDH1A1CYP3A4TDP1 | |
| Hydrochloric Acid SCHEMBL8946354 | 0.85 | ALDH1A1 (0.63) | SMN1; SMN2ALDH1A1CYP3A4TDP1MAPK1 | |
| Ammonia Solution, Strong SCHEMBL1854404 | 0.85 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1CYP3A4TDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6919332-B2 | N-substituted-heteroaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors | PFIZER INC. (US) | 2005-07-19 | — | — | US | disclosed |
| EP-1507535-A1 | PYRIMIDINE-2,4,6-TRIONE METALLO-PROTEINASE INHIBITORS | Pfizer Products Inc. (US) | 2005-02-23 | — | — | EP | disclosed |
| US-20030232849-A1 | N-substituted-heteroaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors | PFIZER INC. | 2003-12-18 | — | — | US | disclosed |
| WO-2003090751-A1 | PYRIMIDINE-2, 4, 6-TRIONE METALLO-PROTEINASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2003-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030232849-A1 | N-substituted-heteroaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors | MMP8, MMP9, MMP1 | SMN1; SMN2 2876/4885NR4A1 652/4885LTA4H 301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.