Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.44 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.44 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8009723 | 0.91 | CA1 (0.50) | KDM4EDNM1PRMT3CARM1PRMT6 | |
| SCHEMBL12583973 | 0.80 | CYP2C19 (0.50) | KDM4ECYP2C19CYP1A2CYP2D6SMN1; SMN2 | |
| SCHEMBL19374828 | 0.79 | DNM1 (0.40) | KDM4EDNM1PRMT3CARM1PRMT6 | |
| SCHEMBL13609675 | 0.79 | DNM1 (0.46) | KDM4EDNM1PRMT3CARM1PRMT6 | |
| SCHEMBL836639 | 0.79 | PRMT3 (0.46) | DNM1PRMT3CARM1PRMT6PRMT1 | |
| SCHEMBL9702686 | 0.79 | DNM1 (0.46) | KDM4EDNM1PRMT3CARM1PRMT6 | |
| SCHEMBL7241259 | 0.78 | ALDH1A1 (0.48) | KDM4EDNM1CA1CA2CA12 | |
| Hydrochloric Acid SCHEMBL10442360 | 0.77 | DNM1 (0.44) | KDM4EDNM1PRMT3CARM1PRMT6 | |
| SCHEMBL3760523 | 0.77 | DNM1 (0.44) | KDM4EDNM1PRMT3CARM1PRMT6 | |
| SCHEMBL3760526 | 0.77 | DNM1 (0.44) | KDM4EDNM1PRMT3CARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-A4 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1465631-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI Pharmaceuticals, Inc. (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003053366-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARMACEUTICALS, INC. (US) | 2003-07-03 | — | — | WO | disclosed |