Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 11/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6184723 | 0.82 | MMP13 (0.39) | MMP13MEN1LMNAKMT2AKDM4E | |
| SCHEMBL6106895 | 0.74 | MMP13 (0.47) | MMP13TBXAS1MEN1LMNAKMT2A | |
| SCHEMBL6105777 | 0.71 | MMP13 (0.51) | MMP13TBXAS1MEN1LMNAKMT2A | |
| SCHEMBL6184736 | 0.70 | NAMPT (0.42) | MMP13MEN1LMNAKMT2AALDH1A1 | |
| SCHEMBL6104600 | 0.69 | TBXAS1 (0.44) | MMP13TBXAS1MEN1LMNAKMT2A | |
| SCHEMBL6105905 | 0.68 | TBXAS1 (0.47) | MMP13TBXAS1MEN1LMNAKMT2A | |
| SCHEMBL6104759 | 0.65 | TBXAS1 (0.44) | MMP13TBXAS1MEN1LMNAKMT2A | |
| SCHEMBL4492287 | 0.65 | CYP19A1 (0.75) | TBXAS1MEN1LMNAKMT2ACYP19A1 | |
| SCHEMBL5697294 | 0.64 | MMP13 (0.77) | MMP13TBXAS1CYP19A1 | |
| Hydrochloric Acid SCHEMBL9853939 | 0.64 | CYP19A1 (0.73) | TBXAS1MEN1LMNAKMT2ACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537098-A1 | MONOCYCLIC DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004014892-A1 | MONOCYCLIC DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |