SCHEMBL6185635

SCHEMBL6185635

[CH2]c1ccc2cc(O)c(O)cc2c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LCK P06239 1/20 0.45
ALOX5 P09917 1/20 0.37
CYP3A4 P08684 2/20 0.36
ALOX15 P16050 2/20 0.36
HIF1A Q16665 2/20 0.36
HSD17B10 Q99714 2/20 0.36
TSHR P16473 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
CYP1A2 P05177 2/20 0.35
KDM4E B2RXH2 1/20 0.35
CA12 O43570 1/20 0.35
ALDH1A1 P00352 1/20 0.35
LMNA P02545 1/20 0.35
BCHE P06276 1/20 0.35
GLA P06280 1/20 0.35
GAA P10253 1/20 0.35
MAPT P10636 1/20 0.35
AKR1B1 P15121 1/20 0.35
HPGD P15428 1/20 0.35
ACHE P22303 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1178667 0.83 CYP2A6 (0.37) CYP3A4ALOX15HIF1AHSD17B10TSHR
SCHEMBL5997236 0.79 CYP3A4 (0.58) CYP3A4ALOX15HIF1AHSD17B10TSHR
SCHEMBL536732 0.76 ALDH1A1 (0.50) CYP3A4ALOX15HIF1AHSD17B10TSHR
SCHEMBL2463315 0.76 ALDH1A1 (0.50) CYP3A4ALOX15HIF1AHSD17B10TSHR
SCHEMBL188205 0.75
SCHEMBL31255814 0.72 LCK (0.43) LCKCYP3A4ALOX15HIF1AHSD17B10
SCHEMBL337114 0.72 LCK (0.43) LCKCYP3A4ALOX15HIF1AHSD17B10
SCHEMBL36452 0.72 CYP2A6 (0.48) CYP3A4ALOX15HIF1AHSD17B10TDP1
SCHEMBL3203555 0.72 CYP1A2 (0.62) LCKCYP3A4ALOX15HIF1AHSD17B10
SCHEMBL27905829 0.70 CYP2A6 (0.46) CYP3A4ALOX15HIF1AHSD17B10TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1507764-A4 NOVEL ENANTIOMERS OF TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS YUN-CHOI HYE-SOOK (KR) 2005-06-22 EP disclosed
EP-1507764-A1 NOVEL ENANTIOMERS OF TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS Yun-Choi, Hye-Sook (KR) 2005-02-23 EP disclosed
WO-2003095426-A1 NOVEL ENANTIOMERS OF TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS YUN-CHOI HYE-SOOK (KR) 2003-11-20 WO disclosed