Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | STK17B | O94768 | 1/20 | 0.48 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.48 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.48 |
| ▸ | DAPK2 | Q9UIK4 | 1/20 | 0.48 |
| ▸ | F2R | P25116 | 4/20 | 0.47 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6188945 | 0.82 | KMT2A (0.44) | ALDH1A1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6186843 | 0.81 | ALDH1A1 (0.40) | ALDH1A1HPGDKMT2ARAB9AKDM4E | |
| SCHEMBL6187358 | 0.81 | F2R (0.51) | DAPK3STK17BDAPK1STK17ADAPK2 | |
| SCHEMBL6185825 | 0.81 | TYK2 (0.45) | ALDH1A1HPGDLMNAMEN1KMT2A | |
| SCHEMBL6189327 | 0.80 | HPGD (0.46) | DAPK3STK17BDAPK1STK17ADAPK2 | |
| SCHEMBL6185706 | 0.79 | MAOB (0.42) | ALDH1A1HPGDLMNAMEN1KMT2A | |
| SCHEMBL6186285 | 0.78 | MAOA (0.49) | STK17BSTK17AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL6186608 | 0.78 | ALDH1A1 (0.42) | ALDH1A1HPGDLMNAMEN1KMT2A | |
| SCHEMBL6185134 | 0.77 | MAOA (0.54) | STK17BSTK17AALDH1A1HPGDLMNA | |
| SCHEMBL6188852 | 0.75 | RAB9A (0.55) | ALDH1A1LMNAMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554271-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004035571-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2004-04-29 | — | — | WO | disclosed |